What is Radiofrequency Ablation (RFA)?

RFA stands for Radio Frequency Ablation. RFA is successfully used to treat certain tumors of lung, liver, kidney, and bone. Radiofrequency energy oscillation agitates cells thereby increasing the frictional heating with in tissues resulting in cell death. The feasibility of lung RFA has been demonstrated in animals, and the feasibility, safety and long term efficacy of lung RFA to treat tumors have been reported in humans, both in the United States and internationally . During the RFA procedure, rapidly alternating current is applied with a frequency in the range of 460-500 kHz through the RFA electrode . The alternating current causes movement of ions in the tissue resulting in tissue heating. Applying a temperature greater than 50 degrees centigrade for five minutes results in tumor cell death. Too high a temperature is not desirable as it will cause charring and gas formation immediately adjacent to the electrode and prevent the homogeneous heating of the entire tumor. During RFA, reaching a temperature of 60-100 degrees centigrade within the tumor is generally desired, as charring and gas formation occur at approximately 105-115 degrees centigrade. Ideally, the goal is to achieve complete cell death within the tumor, as well as in a 1 cm margin of the adjacent normal lung .